Synthesis Process Of Omarigliptin Intermediate CAS 951127-25-6  

      Omarigliptin intermediate CAS number 951127-25-6, also as know as CPo3604-01 intermediate,molecular formula: C16H19F2NO4, molecular weight: 327.32, his synthesis process is as following: 31.2g NaOH was dissolved in water and methanol mixture, the ethanol refrigerant was cooled to 0℃, and after 30 minutes, 57.3 ml of 2,5-difluorobenzaldehyde and 42.6 ml of nitromethane were added dropwise. After the reaction, The mixture was neutralized with acetic acid, stirred with ethyl acetate, and the organic layer was washed successively with sodium carbonate solution and brine, dried over anhydrous sodium sulfate, filtered and concentrated to give 2-nitro-1 (2,5- 112 g of difluorophenyl)-ethanol, hereinafter referred to as intermediate I. 100g of intermediate I was dissolved in 200ml of acetone and cooled to 0℃, 90g of Jones reagent was added dropwise, the temperature of the reaction solution was maintained at 3 ℃, after the reaction was completed, the reaction…